Two of the NFL’s most explosive offenses take center stage Thursday night when the Detroit Lions visit the Buffalo Bills to kick off Week 2 of the 2026 season. Both teams enter at 1-0 after winning one-score games in Week 1.
Jan 4, 2026; Orchard Park, New York, USA; Buffalo Bills quarterback Josh Allen (17) warms up before a game against the New York Jets at Highmark Stadium. Mandatory Credit: Mark Konezny-Imagn Images
How to Watch Bills vs Lions
- When: Thursday, September 17, 2026
- Time: 8:15 PM ET
- TV Channel: Prime Video
- Live Stream: Prime (try for free)
Detroit survived a late push from New Orleans to secure a 31-30 victory in its opener, and now Jared Goff and company face a quick turnaround for their first road game. The Lions have an impressive collection of playmakers around Goff, headlined by Jahmyr Gibbs and Amon-Ra St. Brown, but they’ll be facing a Buffalo team coming off a 36-point performance against Houston.
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The spotlight will be especially bright on Josh Allen as Buffalo unveils its new home in Orchard Park. The Bills will play their first regular-season game at the new Highmark Stadium, adding another layer to an already intriguing matchup between teams with postseason aspirations. The Thursday Night Football opener begins at 8:15 PM ET on Prime Video.
This is a great NFL matchup you will not want to miss; make sure to tune in and catch all the action.
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